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Methionine sulfone

Methionine sulfone is the organic compound with the formula CH 3 SO 2 CH 2 CH 2 CH(NH 2 )CO 2 H . Although it is an amino acid that occurs naturally, it is formed post-translati...

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Methionine sulfone is the organic compound with the formula CH3SO2CH2CH2CH(NH2)CO2H. Although it is an amino acid that occurs naturally, it is formed post-translationally, arising by the double oxidation of methionine via the intermediate methionine sulfoxide.[1][2] The methionine sulfone residue is found in the enzyme catalase of the bacteriumProteus mirabilis.[3]

References

  1. ↑Bin, P; Huang, R; Zhou, X (2017). "Oxidation Resistance of the Sulfur Amino Acids: Methionine and Cysteine". BioMed Research International. 2017 9584932. doi:10.1155/2017/9584932. PMC 5763110. PMID 29445748.
  2. ↑Lee BC, Dikiy A, Kim HY, Gladyshev VN (2009). "Functions and evolution of selenoprotein methionine sulfoxide reductases". Biochimica et Biophysica Acta (BBA) - General Subjects. 1790 (11): 1471–1477. doi:10.1016/j.bbagen.2009.04.014. PMC 3062201. PMID 19406207.
  3. ↑Buzy, Armelle; Bracchi, Valérie; Sterjiades, Raja; Chroboczek, Jadwiga; Thibault, Pierre; Gagnon, Jean; Jouve, Hélène Marie; Hudry-Clergeon, Gilbert (1995). "Complete Amino Acid Sequence of Proteus mirabilis PR Catalase. Occurrence of a Methionine sulfone in the Close Proximity of the Active Site". Journal of Protein Chemistry. 14 (2): 59–72. doi:10.1007/bf01888363. PMID 7786407.