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PCDHA4

Protocadherin alpha-4 is a protein that in humans is encoded by the PCDHA4 gene . [ 5 ] [ 6 ] [ 7 ] This gene is a member of the protocadherin alpha gene cluster, one of three r...

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Protocadherin alpha-4 is a protein that in humans is encoded by the PCDHA4gene.[5][6][7]

This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.[7]

References

  1. 123GRCh38: Ensembl release 89: ENSG00000204967–Ensembl, May 2017
  2. 123GRCm38: Ensembl release 89: ENSMUSG00000104252–Ensembl, May 2017
  3. ↑"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑Wu Q, Maniatis T (Jul 1999). "A striking organization of a large family of human neural cadherin-like cell adhesion genes". Cell. 97 (6): 779–90. doi:10.1016/S0092-8674(00)80789-8. PMID 10380929. S2CID 6014717.
  6. ↑ Sugino H, Hamada S, Yasuda R, Tuji A, Matsuda Y, Fujita M, Yagi T (abril de 2000). "Organización genómica de la familia de genes de cadherina CNR en ratones y humanos". Genomics . 63 (1): 75–87 . doi : 10.1006/geno.1999.6066 . PMID 10662547 . 
  7. 1 2 "Gen Entrez: PCDHA4 protocadherina alfa 4" .

Lecturas adicionales

  • Yagi T, Takeichi M (2000). " Genes de la superfamilia de las cadherinas: funciones, organización genómica y diversidad neurológica" . Genes Dev . 14 (10): 1169– 80. doi : 10.1101/gad.14.10.1169 . PMID 10817752. S2CID 44844497 .  
  • Nollet F, Kools P, van Roy F (2000). "El análisis filogenético de la superfamilia de las cadherinas permite la identificación de seis subfamilias principales, además de varios miembros solitarios". J. Mol. Biol . 299 (3): 551– 72. doi : 10.1006/jmbi.2000.3777 . PMID 10835267 . 
  • Senzaki K, Ogawa M, Yagi T (2000). " Las proteínas de la familia CNR son receptores múltiples para Reelin" . Cell . 99 (6): 635– 47. doi : 10.1016/S0092-8674(00)81552-4 . PMID 10612399. S2CID 14277878 .  
  • Wu Q, Maniatis T (2000). "Los exones grandes que codifican múltiples ectodominios son una característica distintiva de los genes de protocadherina" . Proc . Natl. Acad. Sci. USA . 97 (7): 3124– 9. doi : 10.1073/pnas.060027397 . PMC 16203. PMID 10716726 .  
  • Wu Q, Zhang T, Cheng JF, et  al. (2001). "Análisis comparativo de la secuencia de ADN de los grupos de genes de protocadherina de ratón y humanos" . Genome Res . 11 (3): 389– 404. doi : 10.1101/gr.167301 . PMC 311048. PMID 11230163 .  
  • Strausberg RL, Feingold EA, Grouse LH, et  al. (2003). "Generación y análisis inicial de más de 15.000 secuencias de ADNc humanas y de ratón de longitud completa" . Proc . Natl. Acad. Sci. USA . 99 (26): 16899– 903. Bibcode : 2002PNAS...9916899M . doi : 10.1073/pnas.242603899 . PMC 139241. PMID 12477932 .  
  • Schmutz J, Martin J, Terry A, et  al. (2004). "La secuencia de ADN y el análisis comparativo del cromosoma 5 humano" ( PDF) . Nature . 431 (7006): 268– 74. Bibcode : 2004Natur.431..268S . doi : 10.1038/nature02919 . PMID 15372022. S2CID 4373053 .  
  • Stelzl U, Worm U, Lalowski M, et  al. (2005). "Una red de interacción proteína-proteína humana: un recurso para anotar el proteoma". Cell . 122 (6): 957– 68. doi : 10.1016/j.cell.2005.08.029 . hdl : 11858/00-001M-0000-0010-8592-0 . PMID 16169070 . S2CID 8235923 .  
  • Resumen de toda la información estructural disponible en el PDB para UniProt : O88689 (Protocadherina alfa-4 de ratón) en el PDBe-KB .