Hispanopedia WikiProstaglandin G2 (PGG2) is an organic peroxide belonging to the family of prostaglandins.[1] The compound has been isolated as a solid, although it is usually used in vivo. It quickly converts into prostaglandin H2, a process catalyzed by the enzyme cyclooxygenase (COX).
Prostaglandin G2 is produced from the fatty acidarachidonic acid. The reaction, a double oxygenation, requires the enzyme COX, which inserts two molecules of O2 into the C-H bonds of the substrate acid.[2][1][3]
References
- ^ abWilfred van der Donk; Tsai Ah-Lim; Kulmacz Richard J. (2002). "The cyclooxygenase reaction mechanism". Biochemistry. 41 (52): 15451–8. doi:10.1021/bi026938h. PMID 12501173.
- ^ Rouzer, Carol A.; Marnett, Lawrence J. (2003). "Mecanismo de oxigenación por radicales libres de ácidos grasos poliinsaturados por ciclooxigenasas". Chemical Reviews . 103 (6): 2239– 2304. doi : 10.1021/cr000068x . PMID 12797830 .
- ^ "Prostaglandina G2" . Santa Cruz Biotechnology, Inc. Consultado el 27 de abril de 2015 .
Categorías :
- prostaglandinas
- Fragmentos de compuestos orgánicos