Riligustilide

Riligustilide is a nonsteroidal phytoprogestogen that is found in Ligusticum chuanxiong.^[1]^[2] It is a very weak agonist of the progesterone receptor (EC₅₀ ≈ 81 μM).^[1] Another compound in the plant, 3,8-dihydrodiligustilide, is also a phytoprogestogen, but is almost 1,000-fold more potent in comparison (EC₅₀ = 90 nM).^[1]

References

^ ^a ^b ^cLim LS, Shen P, Gong YH, Yong EL (2006). "Dimeric progestins from rhizomes of Ligusticum chuanxiong". Phytochemistry. 67 (7): 728–34. Bibcode:2006PChem..67..728L. doi:10.1016/j.phytochem.2006.01.024. PMID 16516938.
^ Ahmed, HMM; Yeh, JY; Lin, WJ; Forsberg, NE; Cheng, WTK; Ou, BR (2014). "Validación de un bioensayo de luciferasa para detectar la actividad progestativa en cerdas jóvenes cuyo estro fue inducido por una hierba uterotónica (Ligusticum chuanxiong)". Livestock Science . 163 : 159–164 . doi : 10.1016/j.livsci.2014.02.012 . ISSN 1871-1413 .