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U-50488

U-50488 is a drug which acts as a highly selective κ-opioid agonist , but without any μ-opioid antagonist effects. [ 1 ] It has analgesic , diuretic and antitussive effects, [ 2...

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U-50488 is a drug which acts as a highly selective κ-opioidagonist, but without any μ-opioidantagonist effects.[1] It has analgesic, diuretic and antitussive effects,[2] and reverses the memory impairment produced by anticholinergic drugs.[3] U-50488 was one of the first selective kappa agonists invented and research on its derivatives has led to the development of a large family of related compounds.[4][5] This compound has never received FDA approval and there are no reported human cases in the literature involving an U-50488 overdose.[6]

See also

References

  1. ↑Von Voigtlander PF, Lewis RA (1982). "U-50,488, a selective kappa opioid agonist: comparison to other reputed kappa agonists". Progress in Neuro-Psychopharmacology & Biological Psychiatry. 6 (4–6): 467–70. doi:10.1016/S0278-5846(82)80130-9. PMID 6298890. S2CID 37011292.
  2. ↑Kamei J (1996). "Role of opioidergic and serotonergic mechanisms in cough and antitussives". Pulmonary Pharmacology. 9 (5–6): 349–56. doi:10.1006/pulp.1996.0046. PMID 9232674.
  3. ↑Hiramatsu M, Kameyama T (September 1998). "Roles of kappa-opioid receptor agonists in learning and memory impairment in animal models". Methods and Findings in Experimental and Clinical Pharmacology. 20 (7): 595–9. doi:10.1358/mf.1998.20.7.485724. PMID 9819804.
  4. ↑Szmuszkovicz J (1999). "U-50,488 and the к receptor: A personalized account covering the period 1973 to 1990". Progress in Drug Research. Vol. 52. pp. 167–95. doi:10.1007/978-3-0348-8730-4_4. ISBN 978-3-0348-9746-4. PMID 10396128.
  5. ↑ Szmuszkovicz J (1999). "U-50,488 y el receptor kappa. Parte II: 1991-1998". Avances en la investigación de medicamentos. Fortschritte der Arzneimittelforschung. Progreso de las Investigaciones Farmacéuticas . 53 : 1– 51. PMID 10616295 . 
  6. ↑ Amin ZM, Rambaran KA, Fleming SW, Cho K, Chacko L, Alzghari SK (diciembre de 2017). "Abordando los peligros de las nuevas sustancias psicoactivas no clasificadas como productos químicos de investigación: el caso del U-50488" . Cureus . 9 ( 12) e1914. doi : 10.7759/cureus.1914 . PMC 5800751. PMID 29441248 .