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Vernolepin

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Vernolepin is a sesquiterpene lactone isolated from the dried fruit of Vernonia amygdalina. It shows platelet anti-aggregating properties[2] and is also an irreversible DNA polymerase inhibitor,[3] hence may have antitumor properties.

References

  1. ↑Laekeman, G. M.; Mertens, J.; Totté, J.; Bult, H.; Vlietinck, A. J.; Herman, A. G. (1 March 1983). "Isolation and Pharmacological Characterization of Vernolepin". Journal of Natural Products. 46 (2): 161–169. Bibcode:1983JNAtP..46..161L. doi:10.1021/np50026a003. PMID 6410002.
  2. ↑Laekeman, G. M.; Clerck, F.; Vlietinck, A. J.; Herman, A. G. (1 January 1985). "Vernolepin: An antiplatelet compound of natural origin". Naunyn-Schmiedeberg's Archives of Pharmacology. 331 (1): 108–113. doi:10.1007/BF00498859. PMID 3934564. S2CID 10373287.
  3. ↑Clayden, Jonathan (2005). Organic chemistry (Reprinted (with corrections). ed.). Oxford [u.a.]: Oxford Univ. Press. pp. 238. ISBN 978-0-19-850346-0.