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JWH-210

JWH-210 is an analgesic chemical from the naphthoylindole family, which acts as a potent cannabinoid agonist at both the CB 1 and CB 2 receptors, with K i values of 0.46 nM at...

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JWH-210 is an analgesic chemical from the naphthoylindole family, which acts as a potent cannabinoid agonist at both the CB1 and CB2 receptors, with Ki values of 0.46 nM at CB1 and 0.69 nM at CB2. It is one of the most potent 4-substituted naphthoyl derivatives in the naphthoylindole series, having a higher binding affinity (i.e. lower Ki) at CB1 than both its 4-methyl and 4-n-propyl homologuesJWH-122 (CB1 Ki 0.69 nM) and JWH-182 (CB1 Ki 0.65 nM) respectively, and than the 4-methoxy compound JWH-081 (CB1 Ki 1.2 nM).[4] It was discovered by and named after John W. Huffman.

JWH-210 may be neurotoxic to animals when administered in high doses.[5]

In the United States, all CB1 receptor agonists of the 3-(1-naphthoyl)indole class such as JWH-210 are Schedule I Controlled Substances.[6]

JWH-210 and JWH-122 were banned in Sweden on 1 October 2010 as hazardous goods harmful to health, after being identified as ingredients in "herbal" synthetic cannabis products.[7][8] The substances JWH-210, JWH-122 and JWH-203 were classified as illegal drugs by the Swedish government as of 1 September 2011.[9]

As of October 2015 JWH-210 is a controlled substance in China.[10]

See also

References

  1. ↑Anvisa (2023-07-24). "RDC Nº 804 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial"[Collegiate Board Resolution No. 804 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-07-25). Archived from the original on 2023-08-27. Retrieved 2023-08-27.
  2. ↑"Stoffe gem. Anlagen zum BtMG". Retrieved 2024-11-23.
  3. ↑ "Ustawa z dnia 15 kwietnia 2011 r. o zmianie ustawy o przeciwdziałaniu narkomanii ( Dz.U. 2011 nr 105 poz. 614 )" . Sistema de Internet Aktów Prawnych . Consultado el 12 de junio de 2011 .
  4. ↑ Huffman JW, Zengin G, Wu MJ, Lu J, Hynd G, Bushell K, et al. (enero de 2005). "Relaciones estructura-actividad para 1-alquil-3-(1-naftoílo)indoles en los receptores cannabinoides CB(1) y CB(2): efectos estéricos y electrónicos de los sustituyentes naftoílo. Nuevos agonistas altamente selectivos del receptor CB(2)". Bioorganic & Medicinal Chemistry . 13 (1): 89– 112. doi : 10.1016/j.bmc.2004.09.050 . PMID 15582455 .  
  5. ↑ Cha HJ, Seong YH, Song MJ, Jeong HS, Shin J, Yun J, et al. (noviembre de 2015). " Neurotoxicidad de los cannabinoides sintéticos JWH-081 y JWH-210" . Biomolecules & Therapeutics . 23 (6): 597– 603. doi : 10.4062/biomolther.2015.057 . PMC 4624077. PMID 26535086 .   
  6. ↑ 21 USC § 812   : Listas de sustancias controladas
  7. ↑ Reglamento del Código de Estatutos de Suecia (2010:1086).
  8. ↑ "Reglamento del Código de Estatutos de Suecia (2010:1086). (pdf)" (PDF) . Archivado del original (PDF) el 28 de julio de 2011. Consultado el 10 de enero de 2011 .
  9. ↑ LVFS 2011:8
  10. ^ "关于印发《非药用类麻醉药品和精神药品列管办法》的通知" (en chino). Administración de Alimentos y Medicamentos de China. 27 de septiembre de 2015. Archivado desde el original el 1 de octubre de 2015 . Consultado el 1 de octubre de 2015 .