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WD40 repeat

The WD40 repeat (also known as the WD or beta-transducin repeat ) is a short structural motif of approximately 40 amino acids , often terminating in a tryptophan - aspartic acid...

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The WD40 repeat (also known as the WD or beta-transducin repeat) is a short structural motif of approximately 40 amino acids, often terminating in a tryptophan-aspartic acid (W-D) dipeptide.[2]Tandem copies of these repeats typically fold together to form a type of circular solenoid protein domain called the WD40 domain.

Structure

WD40 domain-containing proteins have 4 to 16 repeating units, all of which are thought to form a circularised beta-propeller structure (see figure to the right).[3][4] The WD40 domain is composed of about 40 to 60[4] amino acids with a glycine and histidine dipeptide near the N-terminus and a tryptophan and aspartic acid dipeptide most commonly at the C-terminus. Two variable regions are present. The repeats typically form a four-stranded anti-parallel beta sheet or blade. These blades come together to form a propeller with the most common being a seven-bladed beta propeller. The blades interlock so that the last beta strand of one repeat forms with the first three of the next repeat to form the 3D blade structure.[3][4]

Function

WD40-repeat proteins are a large family found in all eukaryotes and are implicated in a variety of functions ranging from signal transduction and transcription regulation to cell cycle control, autophagy and apoptosis.[5] The underlying common function of all WD40-repeat proteins is coordinating multi-protein complex assemblies, where the repeating units serve as a rigid scaffold for protein interactions. The specificity of the proteins is determined by the sequences outside the repeats themselves. Examples of such complexes are G proteins (beta subunit is a beta-propeller), TAFII transcription factor, and E3 ubiquitin ligase.[3][4]

Examples

According to the initial analysis of the human genome WD40 repeats are the eighth largest family of proteins. In all 277 proteins were identified to contain them.[6] Human genes encoding proteins containing this domain include:

Véase también

Referencias

  1. ↑ PDB : 1erj ​;Sprague ER, Redd MJ, Johnson AD, Wolberger C (junio de 2000). "Estructura del dominio C-terminal de Tup1, un correpresor de la transcripción en levadura" . EMBO J. 19 ( 12): 3016–27 . doi : 10.1093/ emboj /19.12.3016 . PMC 203344. PMID 10856245 .  
  2. ↑ Neer EJ, Schmidt CJ, Nambudripad R, Smith TF (septiembre de 1994). "La antigua familia de proteínas reguladoras de las proteínas con repeticiones WD". Nature . 371 ( 6495): 297– 300. Bibcode : 1994Natur.371..297N . doi : 10.1038/371297a0 . PMID 8090199. S2CID 600856 .  
  3. 1 2 3 Smith TF, Gaitatzes C, Saxena K, Neer EJ (mayo de 1999). "La repetición WD40: una arquitectura común para diversas funciones" . Trends Biochem. Sci . 24 (5): 181– 5. doi : 10.1016/S0968-0004(99)01384-5 . PMID 10322433 . 
  4. 1 2 3 4 Li D, Roberts R (diciembre de 2001). "Proteínas con repeticiones WD: características estructurales, función biológica y su implicación en enfermedades humanas" . Cell . Mol. Life Sci . 58 (14 ) : 2085– 97. doi : 10.1007/PL00000838 . PMC 11337334. PMID 11814058. S2CID 20646422 .   
  5. ↑ Stirnimann CU, Petsalaki E, Russell RB, Müller CW (mayo de 2010). "Las proteínas WD40 impulsan las redes celulares". Trends Biochem. Sci . 35 (10): 565– 74. doi : 10.1016/j.tibs.2010.04.003 . PMID 20451393 . 
  6. ↑ Lander ES, Linton LM, Birren B, et al. (febrero de 2001). "Secuenciación y análisis inicial del genoma humano" (PDF) . Nature . 409 (6822): 860–921 . doi : 10.1038/35057062 . PMID 11237011 .  
Este artículo incorpora texto de dominio público Pfam e InterPro : IPR001680